Blar i forfatter "Kang, Wenjing"

Viser treff 1-2 av 2

    • MapToCleave: High-throughput profiling of microRNA biogenesis in living cells 

      Kang, Wenjing; Fromm, Bastian; Houben, Anna J.; Høye, Eirik; Bezdan, Daniela; Arnan, Carme; Thrane, Kim; Asp, Michaela; Johnson, Rory; Biryukova, Inna; Friedländer, Marc R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-16)
      Previous large-scale studies have uncovered many features that determine the processing of microRNA (miRNA) precursors; however, they have been conducted in vitro. Here, we introduce MapToCleave, a method to simultaneously profile processing of thousands of distinct RNA structures in living cells. We find that miRNA precursors with a stable lower basal stem are more efficiently processed and also ...

    • MirGeneDB 2.1: toward a complete sampling of all major animal phyla 

      Fromm, Bastian; Høye, Eirik; Domanska, Diana; Zhong, Xiangfu; Aparicio-Puerta, Ernesto; Ovchinnikov, Vladimir; Umu, Sinan Ugur; Chabot, Peter J; Kang, Wenjing; Aslanzadeh, Morteza; Marmol-Sanchez, Emilio; Urgese, Gianvito; Johansen, Morten; Hovig, Eivind; Hackenberg, Michael; Friedländer, Marc R.; Peterson, Kevin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      We describe an update of MirGeneDB, the manually curated microRNA gene database. Adhering to uniform and consistent criteria for microRNA annotation and nomenclature, we substantially expanded MirGeneDB with 30 additional species representing previously missing metazoan phyla such as sponges, jellyfish, rotifers and flatworms. MirGeneDB 2.1 now consists of 75 species spanning over ∼800 million ...